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Deferred antiretroviral therapy (ART) initiation in ART-naive, HIV-positive persons is associated with a small increase in risk for AIDS-defining cancer. These findings add to the evidence that early ART may reduce risk for non-AIDS-defining cancer. A multinational prospective cohort study is published in Annals of Internal Medicine.

Immediate initiation ART regardless of CD4 cell count has been recommended in all HIV-positive persons since 2015. However, only about half of HIV-positive persons in non-resource-limited settings continue to initiate ART when their CD4 count decreases below 500 cells/L, pictures of cymbalta primarily because of late diagnosis. Incidence of non-AIDS-related and AIDS-related cancer is increasing in HIV-positive persons for a number of reasons and is now a leading cause of death in HIV infection. It is unclear to what extent delayed ART initiation, with its consequences of continued HIV replication and immune deterioration, contributes to the increased risk.

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